Dengue
| Au: Dietz, V; Gubler, D. J; Ortiz, S; Kuno, G; Casta-V‚lez, A; Sather, G. E; Gomez, I; Vergne, E. ----- Ti: The 1986 dengue and dengue hemorrhagic fever epidemic in Puerto Rico: epidemiologic and clinical observations. ----- Fu: P. R. Health Sci. J; 15(3):201-10, Sept. 1996. ----- Re: In 1986 Puerto Rico experienced its eleventh dengue outbreak of this century, but the first with simultaneous transmission of three dengue virus serotypes, and the first with significant numbers of severe and fatal hemorrhagic disease. Overall, 10,659 cases were reported; 1,257 cases were laboratory confirmed as having current or recent dengue infection. Dengue 4 (DEN-4) was the predominant serotype (160/363 isolates, 44 percent) followed by dengue 1 (DEN-1) with 134 isolates (37 percent) and dengue 2 (DEN-2), 69 solates (19 percent). Transmission peaked during September, but large numbers of cases occurred through November. Seventy-one (91 percent) of Puerto Rico's 78 municipalities had laboratory-confirmed cases. Fifty-one percent of all confirmed cases occurred in metropolitan San Juan. Most cases presented clinically as classical dengue fever, but 37 percent of all confirmed cases were reported to have developed some type of hemorrhagic manifestation, and 6 percent reported hematemesis. In addition, 29 laboratory confirmed cases met the WHO case definition for dengue hemorrhagic fever, 3 of which were fatal. Among the 29 laboratory-confirmed cases of dengue hemorrhagic fever/ dengue shook syndrome, virus was isolated from 12; one DEN-1, three DEN-2, and eight DEN-4. Among laboratory confirmed cases, infants less than one year of age were at greater risk of developing dengue hemorrhagic fever/ dengue shook syndrome, hematemesis and any reported hemorrhage than were the other age groups evaluated (Au). |
| Au: Castle, Trevor; Amador, Manuel; Rawlins, Samuel; Figueroa, J. Peter; Reiter, Paul. ----- Ti: Absence of impact of aerial malathion treatment on Aedes aegypti during a dengue outbreak in Kingston, Jamaica. ----- Fu: Rev. Panam. Salud P£blica; 5(2):100-5, feb. 1999. ilus. ----- Re: During an outbreak of dengue fever in Jamaica from October to December 1995, a study was carried out to determine the impact of aerial ultra-low volume malathion treatment on adult Aedes aegypti. This was done by monitoring oviposition rates of the vector in three urban communities in Kingston and by exposing caged mosquitoes both directly and inirectly to the aerial malathion treatment. The insecticide was delivered at a rate of 219 mL/ha between 7:10 a.m. and 8:45 a.m. The results of the study clearly showed that the insecticide application was ineffective in interfering with Aedes aegypti oviposition, and adult mosquitoes held in cages inside dwellings were largely unaffected. Consequently, this type of intervention seemed to have little significant impact in arresting or abating dengue transmission (AU). |
| Ti: Dengue outbreak associated with multiple serotypes--Puerto Rico, 1998. ----- So: MMWR Morb Mortal Wkly Rep. 47(44):952-6, 1998 Nov 13. ----- Ab: Dengue is an acute viral disease caused by any of the four dengue virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4). The principal mosquito vector is Aedes aegypti, which has a worldwide distribution in tropical and many subtropical areas. All four virus serotypes produce a similar illness characterized by fever, headache, myalgias, arthralgias, rash, nausea and vomiting and induce life-long immunity that is specific to the infecting serotype. A small proportion of infected persons may develop the severe form of disease, dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), but with early diagnosis and proper supportive management, fatality rates may be <1%. This report summarizes an epidemic of dengue in Puerto Rico in 1998 associated with multiple dengue serotypes (Au). |
| Au: Vasconcelos PF; da Rosa AP; Coelho IC; Menezes DB; da Rosa ES; Rodrigues SG; da Rosa JF. ----- Ti: Involvement of the central nervous system in dengue fever: three serologically confirmed cases from Fortaleza Cear , Brazil. ----- So: Rev Inst Med Trop Sao Paulo. 40(1):35-9, 1998 Jan-Feb. ----- Ab: Three cases of dengue fever involving the central nervous system (CNS) are reported. All occurred in 1994 during a dengue (DEN) epidemic caused by serotypes DEN-1 and DEN-2. The first case examined was a 17-year-old girl who complained of fever, nuchal rigidity and genital bleeding. Three blood samples were positive by anti-dengue IgM ELISA and showed hemagglutination-inhibition (HI) test titers > or = 1,280. The second case concerned a 86-year-old women with fever, muscle and joint pains, altered consciousness, syncope, nuchal rigidity and meningismus. Her blood sample showed an HI titer of 1:320 for flaviviruses, and an IgM ELISA positive for dengue. The third case was a 67-year-old women with fever, abnormal behaviour, seizures, tremor of extremities, thrombocytopenia, increased hematocrit and leukopenia. The patient suffered a typical case of dengue hemorrhagic fever with ensuing shock and a fatal outcome. A single blood sample showed HI antibodies of > or = 1,280 and an IgM ELISA positive for dengue. No virus could be isolated from any patient by inoculation of blood into C6/36 cells and suckling mice. No other agent of disease was encountered in the patient (Au). |
| Au: Kuno G; Cropp CB; Wong-Lee J; Gubler DJ. ----- Ti: Evaluation of an IgM immunoblot kit for dengue diagnosis. ----- So: Am J Trop Med Hyg. 59(5):757-62, 1998 Nov. ----- Ab: A commercial IgM immunoblot kit was evaluated for dengue diagnosis with a panel of serum specimens collected from patients in a dengue endemic area. The kit is not recommended for use in its present form because of its undesirable rate of false-positive results. However, by substituting internal controls with the reference positive and negative controls that are more representative of those seen in endemic areas and by modifying the positive and negative scoring criteria, sensitivity and specificity of 80.3% and 94.5%, respectively, were obtained. These results are comparable with those obtained with the IgM ELISA on specimens, most of which were obtained from outpatient health care facilities. With further technical modifications, inclusion of a visual guide to ensure scoring standardization, and a more complete elaboration of the limitations of the test, wide application of the kit in diagnostic laboratories should be possible (Au). |
| Au: Thong MK. ----- Ti: Dengue shock syndrome and acute respiratory distress syndrome [letter; comment]. -----Cm: Comment on:/Lancet/1998 Sep 19;352(9132):971-7. -----So: Lancet. 352(9141):1712, 1998 Nov 21. |
| Au: da Costa AI; Natal D. -----Ti: Distribuicao espacial da dengue e determinantes socioeconomicos em localidade urbana no Sudeste do Brasil. / Geographical distribution of dengue and socioeconomic factors in an urban locality in southeastern Brazil. ----- So: Rev Saude Publica. 32(3):232-6, 1998 Jun. ----- Ab: INTRODUCTION: The incidence of dengue (serum type I) in the city of S. Jose do Rio Preto during an epidemic which occurred in the first semester of 1995 is analyzed in terms of geographical areas defined by socioeconomic variables. MATERIAL AND METHOD: The epidemiological method of analysis is the ®ecological study® type. To calculate the coefficient of incidence of dengue, all cases both confirmed and reported between January and July, 1995 are considered. The environmental units are defined according to socioeconomic variables based on the IBGE (Brazilian Institute of Geography and Statistics) Census of 1991, through cluster analysis. The linear correlation coefficient between coefficient of incidence and environmental variables is also calculated. RESULTS AND DISCUSSION: Three distinct environmental units are identified and described on the basis of both economic and educational level. The coefficient of incidence of dengue varied in accordance with the environmental unit: in the unit of low standard the coefficient was 2.7 times greater than that of the unit of highest standard, showing that in these units the determining factors of dengue have a differentiating effect. The roles of some of the determining factors such as population density, basic sanitary services and vector density are discussed. The importance of this study for the control of dengue is also emphasized (Au). |
| Au: Glowacki G; Spinsanti L; Basualdo MA; Diaz G; Contigiani M. ----- Ti: Prevalencia de anticuerpos contra flavivirus en jovenes voluntarios ingresantes al servicio militar de la Provincia de Formosa, Argentina. / Prevalence of Flavivirus antibodies in young voluntary recruits to military service in the province of Formosa, Argentina. ----- So: Rev Argent Microbiol. 30(4):170-5, 1998 Oct-Dec. ----- Ab: The aim of the present study was to investigate the seroprevalence to Flavivirus, in young people living in risk areas. We analyzed 189 human sera from 3 towns in the Province of Formosa. This area corresponds to the border that limits Brasil and Paraguay and the aim was to search for a possible introduction of Dengue and Yellow Fever from these countries. Serological tests such as haemagglutination inhibition (HI), complement fixation (CF) and neutralization (NT) were performed using St. Louis encephalitis (SLE), Bussuquara, Ilheus, Yellow fever and dengue 1 and 2 viruses. No definite evidence for HI antibodies to dengue and Ilheus was obtained. One serum cross-reacted only with yellow fever and two sera only for Bussuquara by the HI test. Only one serum was confirmed to be positive for Bussuquara by NT test. A total of 22 sera from 189 were positive for SLE by the HI test and 40 were also reactive by the NT test. The seroprevalence measured by HI and NT antibodies was similar in the three departments studied. These results show that SLE virus is present in the North of Argentina with an important value of prevalence so that this agent could play an important role in the febrile infections not virologically confirmed (Au). |
| Au: Gascon J; Giner V; Vidal J; Jou JM; Mas E; Corachan M. ----- Ti: Dengue: una enfermedad reemergente. Estudio clinicoepidemiologico en 57 viajeros españoles. / Dengue: a re-emerging disease. A clinical and epidemiological study in 57 Spanish travelers. ----- So: Med Clin (Barc). 111(15):583-6, 1998 Nov 7. ----- Ab: Dengue infection is nowadays considered a re-emergent disease. It has a worldwide tropical and subtropical distribution. The dengue virus in a member of the flavivirus family composed by 4 different serotypes. The virus is transmitted by mosquitos of the Aedes genus. With the increment of travels to the endemic areas, dengue is now observed frequently in our country. We analyzed 57 patients, 30 with imported dengue (ID) and 27 with dengue fever suffered during the trip (DDT). This series is compared with other published ones and a review of the subject is presented. Patients with ID followed a protocol as a febril syndrome returning from the tropics. Dengue was diagnosed through a compatible clinico-epidemiological history, the absence of other ferbil illness and positivity of specific serology. All patients had travelled to endemic areas (Central America 28 cases, Indian subcontinent 15, South-East Asia 10, South America 2, West Africa one, and Pacific one). The following were the most important clinical characteristics: fever and asthenia (100%), headache (98%), mialgia (84%), arthralgia (72%), morbilliform rash (61%) and retroocular pain (65%). For ID cases, the most helpful analitical results were: leucopenia (70%), reactive lymphocytes in peripheral blood smear (70%), thrombocytopenia (70%), and increased hepatic enzymes ALAT (53%), ASAT (63%) and LDH (100% in the 7 patients tested for this enzyme). Dengue must be included in differential diagnosis of fever in patients coming back to travels to tropical areas (Au). |
| Au: Rocco IM; Barbosa ML; Kanomata EH. ----- Ti: Simultaneous infection with dengue 1 and 2 in a Brazilian patient. ----- So: Rev Inst Med Trop Sao Paulo. 40(3):151-4, 1998 May-Jun. ----- Ab: Dengue outbreaks have occurred in several Brazilian States since 1986 involving serotypes 1 (DEN-1) and 2 (DEN-2). In view of the few cases of double infection documented in the literature, we report here a case of simultaneous infection with DEN-1 and DEN-2 in a patient residing in the municipality of Miranda, State of Mato Grosso do Sul, Western region of Brazil. DEN-1 was introduced in this State in 1989 and DEN-2 in 1996, both of them circulating in some municipalities. This double infection was identified by virus isolation and by indirect immunofluorescence using monoclonal antibodies and confirmed by the polymerase chain reaction (PCR). This is the first documented case of simultaneous infection with serotypes DEN-1 and DEN-2 in Brazil (Au). |
| Au: Vazeille-Falcoz M; Mousson L; Rodhain F; Chungue E; Failloux AB. ----- Ti: Variation in oral susceptibility to dengue type 2 virus of populations of Aedes aegypti from the islands of Tahiti and Moorea, French Polynesia. ----- So: Am J Trop Med Hyg. 60(2):292-9, 1999 Feb. ----- Ab: Twenty three samples of Aedes aegypti populations from the islands of Tahiti and Moorea (French Polynesia) were tested for their oral susceptibility to dengue type 2 virus. The high infection rates obtained suggest that the artificial feeding protocol used was more efficient than those previously described. Statistical analysis of the results allowed us to define two distinct geographic areas on Tahiti with respect to the susceptibility of Ae. aegypti: the east coast, with homogeneous infection rates, and the west coast, with heterogeneous infection rates. No geographic differences could be demonstrated on Moorea. The possible mechanisms of this phenomenon are discussed in connection with recent findings on the variability of susceptibility of Ae. aegypti to insecticides (Au). |
| Au: de Silva AM; Dittus WP; Amerasinghe PH; Amerasinghe FP. ----- Ti: Serologic evidence for an epizootic dengue virus infecting toque macaques (Macaca sinica) at Polonnaruwa, Sri Lanka. ----- So: Am J Trop Med Hyg. 60(2):300-6, 1999 Feb. ----- Ab: Dengue is one of the most rapidly emerging diseases in the tropics. Humans are the principal reservoir of dengue viruses. It is unclear if nonhuman primates also serve as a reservoir of human dengue viruses under certain conditions. In this study, a cross-sectional serologic survey was carried out to characterize the pattern of transmission of a recently identified dengue virus among toque macaques in Sri Lanka. The results indicated that an epizootic dengue virus was active among the macaques. A single epizootic had taken place between October 1986 and February 1987 during which 94% of the macaques within the 3 km2 study site were exposed to the virus. The epizootic was highly focal in nature because macaques living 5 km from the study population were not exposed to the virus. The transmission of dengue viruses among macaques in the wild may have important public health implications (Au). |
| Au: Kenyon G. ----- Ti: Scientists try new strategy to eradicate dengue fever [news]. ----- So: BMJ. 318(7183):555, 1999 Feb 27. |
| Au: Castle T; Amador M; Rawlins S; Figueroa JP; Reiter P. ----- Ti: Absence of impact of aerial malathion treatment on Aedes aegypti during a dengue outbreak in Kingston, Jamaica. ----- So: Rev Panam Salud Publica. 5(2):100-5, 1999 Feb. ----- Ab: During an outbreak of dengue fever in Jamaica from October to December 1995, a study was carried out to determine the impact of aerial ultra-low volume malathion treatment on adult Aedes aegypti. This was done by monitoring oviposition rates of the vector in three urban communities in Kingston and by exposing caged mosquitoes both directly and indirectly to the aerial malathion treatment. The insecticide was delivered at a rate of 219 mL/ha between 7:10 a.m. and 8:45 a.m. The results of the study clearly showed that the insecticide application was ineffective in interfering with Aedes aegypti oviposition, and adult mosquitoes held in cages inside dwellings were largely unaffected. Consequently, this type of intervention seemed to have little significant impact in arresting or abating dengue transmission (Au). |
| Au: Vasconcelos PF; Lima JW; da Rosa AP; Timbo MJ; da Rosa ES; Lima HR; Rodrigues SG; da Rosa JF. ----- Ti: Epidemia de dengue em Fortaleza, Cear : inquerito soro-epidemiologico aleatorio. / Dengue epidemic in Fortaleza, Cear : randomized seroepidemiologic survey. ----- So: Rev Saude Publica. 32(5):447-54, 1998 Oct. ----- Ab: OBJECTIVE: A seroepidemiological random survey was carried out in Fortaleza city, State of Cear , Brazil, following an epidemic of dengue virus type 2 (DEN 2), with the purpose of evaluating the frequency of clinical manifestations (signs and symptoms) and the prevalence of dengue infection. METHOD: A questionnaire calling for information on address, sex, age, clinical, epidemiological and economic status was applied to the population, followed by venupuncture collection of 5-10 ml of blood for testing by hemagglutination-inhibition (HI). The sample was calculated to obtain a prevalence of 20% with relative risk of 10% and confidence interval of 95%. All information obtained was analyzed by computer using Epi Info 5.0, Lotus 123, Excel 5.0, and Stata software. RESULTS AND CONCLUSIONS: A total of 1,341 serum samples were obtained from nine Health Districts (SD) and tested by hemagglutination inhibition. Of these, 589 (44%) were positive and 752 (56%) negative. Of the positive results, 93 primary responses (PR) (7%) to DEN-2 and 496 secondary responses (SR) (37%) were observed. The global prevalence in the SD ranged from 21% to 71%. There were 41% (243/589) asymptomatic infections and 59% (346/589) symptomatic infections. Data analysis showed no difference in frequency by sex, age, on schooling, although a highly statistically significant difference was found as between the different social classes, the infection most commonly observed being among people of better social status. The stratification of positive cases showed greater prevalence of AI (p < 0.001) and SI (p < 0.0001) in both sexes, among people with SR rather than PR. The most prevalent symptoms were fever, headache, muscle pains, rash, dizziness, and joint pains. Moreover, itching, retro-bulbar pain, rash, and gingival bleeding, showed statistically significant differences. On the other hand, dizziness and joint pains were more associated in the patients with SR than PR, and statistically significant differences were also observed (Au). |
| Au: Rigau-Perez JG. ----- Ti: Case definition for dengue hemorrhagic fever [letter; comment]. ----- Cm: Comment on:/Pediatr Infect Dis J/1998 Aug;17(8):761-2, 764-5. ----- So: Pediatr Infect Dis J. 18(1):80, 1999 Jan. |
| Au: Vasconcelos PF; Lima JW; Raposo ML; Rodrigues SG; da Rosa JF; Amorim SM; da Rosa ES; Moura CM; Fonseca N; da Rosa AP. ------ Ti: Inquerito soro-epidemiologico na ilha de Sao Luis durante epidemia de dengue no Maranhao. / A seroepidemiological survey on the island of Sao Luis during a dengue epidemic in Maranhao. ----- So: Rev Soc Bras Med Trop. 32(2):171-9, 1999 Mar-Apr. ----- Ab: The island of Sao Luis in the State of Maranhao, constituted by the municipalities of Sao Luis-SL (835,428 inhabitants), Sao Jos‚ de Ribamar-SJR (60,633 inhabitants) and Pa‡o do Lumiar-PL (80,274 inhabitants), has been suffering dengue (DEN) fever epidemics since 1995, caused by DEN-1. In 1996, from August through October, an aleatory sero-epidemiologic survey was carried out in order to estimate the incidence of DEN infection and to analyze other clinical and epidemiological parameters. A questionnaire was applied and serum samples were simultaneously obtained. Serum samples were tested by hemagglutination inhibition (HI). Results were analyzed using Lotus 123, Epi-info 6.0, Excel 5.0 and STATA softwares. A total of 1,217 serum samples were obtained (101 of PL, 100 of SJR and 1017 of SL). The rate of DEN was 55.4% in PL, 28% in SJR and 41.4% in SL, suggesting the occurrence of 401,933 infections. No difference was seen between males and females, but infection occurred more in the upper social class than in poor people (p < 0.003), and was more frequent in adults than in children (p < 0.0004). In SL, the incidence was stratified into seven sanitary districts (SD), and prevalence was found to range from 26.1% in SD4 to 56.8% in SD1 (p < 0.0001). Symptoms were more frequently reported by people whose HI was positive: they included fever, headache, chills, dizziness, retrobulbar pains, muscle and joint pains, nausea, anorexia and skin rash. In spite of the high incidence of infection, no hemorrhagic cases were reported (Au). |
| Au: Vaughn DW; Nisalak A; Solomon T; Kalayanarooj S; Nguyen MD; Kneen R; Cuzzubbo A; Devine PL. ----- Ti: Rapid serologic diagnosis of dengue virus infection using a commercial capture ELISA that distinguishes primary and secondary infections. ----- So: Am J Trop Med Hyg. 60(4):693-8, 1999 Apr. ----- Ab: A commercial capture ELISA for specific IgM and IgG antibodies produced during dengue infection (PanBio Dengue Duo) showed excellent sensitivity (99%, n = 78) using sera collected at hospital discharge compared with established ELISA and hemagglutination inhibition (HAI) assays. Furthermore, the ELISA was able to diagnose 79% of the dengue cases using sera collected at hospital admission. The ELISA also showed high specificity (92%) in paired sera from patients without flavivirus infection (n = 26), although 45% of the patients with Japanese encephalitis (n = 20) showed elevation of IgG but not IgM. The IgG capture ELISA showed good correlation with the HAI assay (r = 0.83, P < 0.0001), and IgG levels could be used to distinguish between primary and secondary infection, with 100% of primary infections and 96% of secondary infections being correctly classified. This ELISA should prove useful in the clinical diagnosis of dengue infections (Au). |
| Au: Nogueira RM; Miagostovich MP; Schatzmayr HG; dos Santos FB; de Araujo ES; de Filippis AM; de Souza RV; Zagne SM; Nicolai C; Baran M; Teixeira Filho G. ----- Ti: Dengue in the State of Rio de Janeiro, Brazil, 1986-1998. ----- So: Mem Inst Oswaldo Cruz. 94(3):297-304, 1999 May-Jun. ----- Ab: This paper presents epidemiological, laboratory, and clinical data on 12 years of dengue virus activity in the State of Rio de Janeiro from the time the disease was first confirmed virologically in April 1986 through April 1998. DEN-1 and DEN-2 viruses are the serotypes circulating in the state and were responsible for the epidemics reported during the last 12 years. The results published here show both the impact of dengue virus infections on the population and laboratory advances that have improved dengue diagnosis (Au). |
| Au: Barbosa, Maria Luisa; Ueda-Ito, Marli; Rocco, Iray Maria. ----- Ti: Presenca de virus endogeno na linhagem celular Aedes albopictus Clone C6/36 nao infectadas / Presence of an endogenous virus in uninfected Aedes albopictus Cell, Clone C6/36. ----- Fu: Rev. Inst. Adolfo Lutz; 57(2):31-3, dez.1998. ----- Re: As linhagens celulares obtidas a partir de larvas do mosquito Aedes albopictus apresentam-se naturalmente infectadas por virus. O clone C6/36 dessas celulas, obtido por Igarashi em 1978, mostrou estar livre de virus e tem sido usado para isolamento do virus Dengue na maioria dos laboratorios especializados. Em nossos estudos com esse clone, apos diferentes periodos de incubacao, detectamos a presen‡a de um virus endogeno. Sobrenadante de cultura de c‚lulas C6/36, apos o a 12§ dia de repique, analisado por coloracao negativa em microscopia eletronica, revelou a presenca de particulas virais sem envoltorio, medindo cerca de 20nm. Esse mesmo teste, quando realizado com celulas apos o 2§, 6§ e 10§ dias de incubacao, resultou negativo. As celulas tambem foram submetidas … imunofluorescencia indireta utilizando anti soros para varios grupos de arbovirus. Os resultados foram negativos, descartando a possibilidade de contaminacao laboratorial. A presenca de virus endogeno em celulas C6/36 pode ocorrer em diferentes laboratorios, sem detectada. Nossos resultados mostram que esse virus endogeno nao influencia o isolamento do virus Dengue e a replicacao das celulas. Em razao da ausencia de dados, o emprego dessas celulas para isolamento de outros virus deve ser cuidadosamente avaliado (AU). |
| Au: Vasconcelos, Pedro Fernando da C; Lima, Jose W. O; Raposo, Maria L; Rodrigues, Sueli G; Rosa, Jorge F. S. Travassos da; Amorim, S¡lvia M. C; Rosa, Elizabeth S. Travassos da; Moura, Cleide M. P; Fonseca, Niedja; Rosa, Amelia P. A. Travassos. ----- Ti: Inquerito soro-epidemiologico na Ilha de Sao Luis durante epidemia de dengue no Maranhao / Seroepidemiologic survey in Sao Luis Island, State of Maranhao, Brazil, during a dengue fever epidemies. ----- Fu: Rev. Soc. Bras. Med. Trop; 32(2):171-79, mar.-abr. 1999. tab, graf. ----- Re: Nos anos de 1995 e 1996, ocorreu em Sao Luis uma epidemia de dengue (DEN), causada pelo sorotipo DEN1. Objetivando avaliar o impacto da mesma na populacao da grande Sao Luis (municipios de Paco do Lumiar - PL, Sao Jose de Ribamar - SJR e Sao Luis SL), realizamos um inquerito soro epidemiologico aleatorio, onde aplicamos um question rio. Os soros foram testados por inibicao da hemaglutinacao (IH) e os resultados negativo e positivo (resposta primaria - RP e resposta secund ria RS), foram analisados utilizando os "software's" Lotus 123, Epi-info 6.0. Excel 5.0 e STATA. Coletaram-se 1277 amostras, (101 de PL, 100 de SJR e 1016 de SL). A positividade foi: 55,4 por cento em PL, 28 por cento em SJR e 41,4 por cento em SL. Destes, 505(4.1,2 por cento) amostras foram positivas sendo 96 RP (7,9 por cento) e 405 RS (33,3 por cento). Da amostra obtida, 508 soros (227 positivos) foram do sexo masculino e 709 (278 positivos) do feminino, nao havendo diferen‡a estat¡stica significativa. Houve significancia (p < 0,003) na estratificacao de acordo com a renda, sendo mais frequente nas populacaes com melhor n¡vel socio economico. Estimou-se em 401.933 infeccaes causadas pelo virus dengue. Os pacientes referiram febre, cefaleia, calafrios, tonturas, astenia, dor retro ocular, mialgia, artralgia, nauseas, anorexia, prurido e exantema. Ha uma grande populacao sensibilizada pelo DEN-1, suscetivel a outro sorotipos o que aumenta o risco de dengue hemorragico (AU). |
| Au: Oliveira, Solange Artimos de; Camacho, Lu¡s A. B; Bettini, Lilian Rachel; Fernandes, Daniele Guerreiro; Gouvea, Nathalia A. C; Barros, Roberto A. Q; Setubal, Sergio; Siqueira, Marilda Mendonca. ----- Ti: Manifestacaes articulares nas viroses exantematicas / Joint complaints in exanthematic diseases. ----- Fu: Rev. Soc. Bras. Med. Trop; 32(2):125-30, mar.-abr. 1999. tab. ----- Re: A frequencia de manifestacaes articulares foi avaliada em 251 pacientes com diagnostico clinico e laboratorial (deteccao de IgM por ensaio imunoenzim tico) de virose exantematica. As artropatias (artralgia e/ou artrite) foram mais observadas nos casos de dengue (49 por cento) e de rubeola (38,2 por cento) do que naqueles com parvovirose humana (30 por cento) e sarampo (28,1 por cento). Com excecao do sarampo, as artropatias predominaram nos adultos (>/= 15 anos de idade), sendo tal diferenca estatisticamente signinficativa. A ocorrencia maior de artropatias em adultos foi mais evidente nos pacientes com parvovirose (75 por cento), rubeola (65 por cento) e dengue (57,7 por cento) do que naqueles com sarampo (31 por cento). As queixas articulares tambem predominaram nos pacientes do sexo feminino para todas as viroses avaliadas. Os resultados encoontrados demonstram o frequente acometimento articular nas doencas estudadas, e indicam a necessidade de comprovacao laboratorial para o diagnostico diferencial entre elas (AU). |
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